Test different grain and manufacture in your gun. What works out of one gun, might not workout of an identical gun. I spent sometime at the public ranges this year, watching guys sight in there muzzleloaders and slug guns. I realized that many guys out there don't have a clue at how to sight in a gun. They staple a target or pie plate to wood and if they can hit it at a give range then thats good enough. No rests, no grouping, no dialing it in. If it hit the target that good enough. I like to play around with the gun and see what it likes. I did know that my muzzleloader loves 110 grains of powder (2-30 grain pellet and 1 50 grain) it hold 1 3/4 groups at 100 yards. With 150 grains it shoots 3" groups... imagine that and I don't feel short changed by not shooting the max. Accuracy over knock down power, anytime. Sighting in is fun, not work. Enough chat for now, get a ballistics book and practice around with different loads.
Ryan