Another factor would be the rest you are using. If it is a WB then the blazers will hold up much better than the cheap 4" vanes. If it is a hostage rest blazers may cause contact issues so the 4" lower profile vanes would be better. If it is a drop away either should work if the rest is set up properly. I use blazers for most of my hunting arrows.
I put half of my arrows with 4" and half with the blazers, they all shoot tight with field tips. When I shoot my broadheads "G5 Montec 100gr." the blazers fly straighter and hit the 4" mark from 20 yards easily!!! Just remember you need your broad head "if fixed" to match as close to possible as the veins you have on there so they fly the best!
Shoot a whisker biscuit with Blazers. No clearance issues and after shooting over a year with them I had to replace the biscuit but the blazers are holding up fine. By the way they are flecthed with Fletch-tite platinum and 2 deg offset.